• Alex Kidd - The Enchanted Castle
• Altered Beast
• Bonanza Brothers
• Columns
• Comix Zone
• Decap Attack starring Chuck D.Head
• Ecco the Dolphin
• Ecco: The Tides of Time
• Ecco Jr.
• Kid Chameleon
• Flicky
• Gain Ground
• Golden Axe I
• Golden Axe II
• Golden Axe III
• Phantasy Star II
• Phantasy Star III: Generations of Doom
• Phantasy Star IV: The End of the Millenium
• Ristar
• Shinobi III
• Sonic the Hedgehog 1
• Sonic the Hedgehog 2
• Super Thunder Blade
• Sword of Vermilion
• Vectorman 1
• Vectorman 2
• Virtua Fighter 2
• Games unique to the PSP collection - Unlockables
• Astro Blaster
• Tip Top
• Eliminator
• Space Fury
• Super Zaxxon

SEGA Mega Drive Collection features over 30 titles including, Altered Beast, Sonic The Hedgehog, Shinobi III, Phantasy Star, and the original SEGA Mega Drive version of Golden Axe. The games in the collection have been reproduced with the utmost accuracy to the originals as possible. SEGA Mega Drive Collection also features numerous unlockable items that delve into the soul of the Mega Drive including interviews with the original developers that created the games featured in the collection, a museum area with interesting facts about the games, a hint area to help gamers complete their favorite SEGA Mega Drive games.SEGA Mega Drive Collection for the PSP system marks the handheld debut of numerous titles in the collection. The PSP's wireless function will for the first time ever allow Mega Drive fans to connect with friends for a wireless multiplayer gaming experience.