In Onimusha 3 the stage is set in the year 1582 at the burning Honnoji Temple, as the famous Onimusha warrior Samanosuke Akechi fights. As he faces the demons in front of him, he is compelled to move forward by hatred for his true enemy, the undying Nobunaga Oda, ever pursuing his crazed ambition. Samanosuke prepares for the long-awaited final battle against Nobunaga.

The year is now 2004 and Jean Reno plays Jacques Blanc as the peaceful French capital is suddenly attacked by demons. In the blink of an eye, Paris is transformed into a nightmarish nest of Genma demons who are slaughtering the civilians and soldiers one by one. Within this nightmare appears one man, a man who stands up against the Genma demons.

Why has Samanosuke suddenly appeared in present Paris and Jacques in feudal Japan? What fate awaits these two men? What will be the final outcome of each of their stories? Find out the truth when you play the game